Harmonization of definitions and creation of a joint research agenda
Objective
To establish community-accepted definitions and a common research agenda based on priorities identified by the community to deepen our understanding of mechanisms in Resolution Biology
Tasks
- T1.1: Creation of consensus definitions and criteria;
- T1.2: Conduction of a community based survey to identify challenges in the study of Resolution Biology;
- T1.3: Collation of results from the survey and prioritization of challenges to establish a joint agenda.
- T1.4: YRI training in research coordination.
Leaders
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WG1 CoLeaderOlga PechanovaCentrum Experimentalnej Mediciny Slovenskej Akademie Vied, Verejna Vyskumna Institucia
Slovakia -
WG1 ECI CoLeaderMarcela Hortova KohoutkovaFakultni Nemocnice U Sv. Anny V Brne
Czech Republic
United KingdomDevelopment of Standard Operating procedures (SOP)
Objective
To establish standardised protocols and methodologies for the study of Resolution Biology
Tasks
- T2.1: Collation of methodologies employed in research (including in vitro, in vivo and analytical methodologies) into Resolution Biology;
- T2.2: Streamlining the methodologies to harmonize approaches in SOP;
- T2.3: Consultation with the community on proposed SOP.
- T2.4: YRI training in SOP & method development
Leaders
Germany
Italy
Defining mechanisms that regulate the resolution of inflammation
Objective
Synergy between multidisciplinary and multisectoral efforts in the study of mechanisms in Resolution Biology to enable ground-breaking discoveries
Tasks
- T3.1: Identify and aggregate areas of active research into cross-cutting themes to foster synergy;
- T3.2: Establish and characterise novel tools (e.g., transgenic animals, organchip models etc.);
- T3.3: Establish mechanisms of cross talk between pro-resolving pathways;
- T3.4: Establish the role of pro-resolving pathways in physiology;
- T3.5: Identify mechanisms that lead to dysregulated pro-resolving pathway activity in disease.
- T3.6: Educational video(s) highlighting the role of Resolution Biology in physiology.
- T3.7:Training of YRI in basic discovery science and cutting-edge methodologies.
Leaders
Ireland
SwedenIdentify novel Resolution Biology-based targets
Objective
To leverage multidisciplinary and multisectoral expertise to develop and test novel Resolution Biology-based targets for the treatment of chronic inflammatory conditions
- T4.1: Identify areas of fragmented expertise and organise these into cross cutting themes to foster synergy;
- T4.2: To establish guidelines for the development of novel Resolution Biology-based therapeutics to facilitate translation.
- T4.3: Establish the therapeutic potential of available Resolution Biology-based leads;
- T4.4: To identify novel proresolving mediator-based prognostic and/or diagnostic biomarkers.
- T4.5: Educational video(s) highlighting the potential utility of resolution-based drugs.
- T4.6 Training of YRI in the translation and commercialization of basic research
- SubWG4.1 New targets and therapies
Leader: Dr. Leonardo Martin
Department of Pharmaceutical Sciences, University of Antwerp, Belgium - SubWG4.2: New technologies
Leader: Dr. Débora Ferreira
Centre of Biological Engineering (CEB) – University of Minho (UM, Braga) - SubWG4.3: Clinical translation
Leader: Dr. Martin Schlegel
Department of Anesthesiology and Intensive Care Medicine, TUM University Hospital, Munich, Germany
Leaders
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WG4 LeaderJoan ClàriaConsorci Institut D'investigacions Biomediques August Pi I Sunyer
Spain -
WG4 CoLeaderJuan Bautista De SanctisInstitute of Molecular and Translational Medicine. Faculty of Medicine and Dentistry. Palacky University Czech Republic -
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Establishing a curated knowledge hub
Objective
To establish an open access, up-to-date online resource that brings together the existing knowledge about Resolution Biology and provide a platform for the dissemination of guidelines and research emanating from this action
Tasks
- T5.1: Collate available knowledge into research domains;
- T5.2: Design and establish an interactive database that provides a gateway to the collated knowledge;
- T5.3: Curate the database to ensure all the information is up to date.
- T5.4: YRI training in database development and management.
Leaders
Netherlands
Science communication, dissemination and exploitation
Objective
To implement activities to ensure knowledge sharing between partners, to organise the training activities together with WG1-4, defining and implementing the dissemination and exploitation plan
Tasks
- T6.1: Create and publish a website and social media accounts for this action;
- T6.2: Facilitate the integration of the database working with WG5;
- T6.3: Define and implement dissemination and exploitation plan;
- T6.4: Organize networking and training (including STSMs, workshops and schools) activities with WG1-5;
- T6.5: Organise outreach and communication activities including participation in third party activities.
- T6.6 YRI training in research dissemination and exploitation.
- T6.7 Onboarding of new participants in this COST during the implementation phase.
Leaders
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Science Communication Coordinator, WG6 LeaderTeresa SousaFaculdade de Medicina da Universidade do Porto
Portugal -
Science Communication Coordinator, WG6 CoLeaderSaara LaitinenFinnish Red Cross Blood Service
Finland -
WG6 ECI CoLeaderCarolina Silva-PereiraFaculdade de Medicina da Universidade do Porto Portugal -
