Description of the project
The COST Action EU-RESOLVE CA24138 aims to advance our understanding of the biological processes that regulate the resolution of inflammation and accelerate the translation of these findings into more effective treatments for patients suffering from acute and chronic diseases.
Despite significant advances in understanding the mechanisms driving inflammation-associated diseases and the development of new therapeutics, the socio-economic burden of these conditions within the EU remains disproportionately high. This underscores the urgent need for more effective therapies to treat acute and chronic diseases.
In the recent years, there has been a paradigm shift in our understanding of how inflammation resolves, with the discovery that its resolution is an actively regulated biochemical and cellular process. While our knowledge of these processes has expanded considerably, significant gaps remain in understanding the mechanisms that govern the resolution of inflammation. Bridging these gaps would not only enhance our understanding of fundamental biological processes but also offer insights into disease mechanisms and open new opportunities for treating inflammatory conditions by targeting the resolution pathways.
EU-RESOLVE aims to create a multidisciplinary, pan-European network of excellence in Resolution Biology. This network will bring together academics, clinicians, biotechnology companies, and other stakeholders to:
- Consolidate fragmented expertise to foster synergy through the sharing of state-of-the-art knowledge and innovative techniques.
- Provide cutting-edge and innovative training to build research and clinical capacity.
- Establish an open-access, integrated database to serve as an educational resource for the research and clinical communities.
Specific Objectives
Research Coordination
- Objective 1 (RCO1): Develop consensus definitions and methodologies for the study of Resolution Biology
- Objective 2 (RCO2): Develop standard operating procedures for experimental models, clinical approaches, and analytical methodologies
- Objective 3 (RCO3): Promote multidisciplinary and multisectoral collaboration to favour skills exchange and enable breakthrough advances in Resolution Biology
- Objective 4 (RCO4): Enable multisectoral and multidisciplinary exchanges to facilitate identification of new opportunities for breakthrough advances in Resolution Biology
- Objective 5 (RCO5): Delivery of an open access curated online resource that collates up-to-date information (including definitions, standard operation procedures (SOPs), publications) on Resolution Biology.
- Objective 6 (RCO6): Dissemination of findings and resources to community and stakeholders
Capacity-building Objectives
- Objective 1 (CBO1): Establish an educational platform (and associated educational series, videos, Q&A)
- Objective 2 (CBO2): Identify and develop a strong network of Expert Centres to establish a pan-European resolution research consortium
- Objective 3 (CBO3): Set up a multicultural, transnational comprehensive research network bringing together a comprehensive and a unique group of basic and clinical expertise from across the world to jointly develop ideas and new global initiatives of applied Resolution Biology
- Objective 4 (CBO4):Train the new generation of experts and leaders (young researchers and innovators -YRIs) with creative mindsets and bridging basic and clinical research.
- Objective 5 (CBO5):Promote mobility, diversity and equality in research across the EU and the participation of any and all genders, and researchers from Inclusive Target Countries (ITCs) and the inclusion of people with disabilities.
- Objective 6 (CBO6):Act as a bridge between Resolution science and relevant stakeholders from pharmaceutical industry, clinical decision makers, policy makers, patient associations, and the general public on diagnosis, treatment and awareness on the role of failed inflammation resolution in disease onset and progression.